- published: 26 Sep 2023
- views: 1029
"Low" is the debut single by American rapper Flo Rida, featured on his debut studio album Mail on Sunday and also featured on the soundtrack to the 2008 film Step Up 2: The Streets. The song features fellow American rapper T-Pain and was co-written with T-Pain. There is also a remix in which the hook is sung by Flo Rida rather than T-Pain. An official remix was made which features Pitbull and T-Pain. With its catchy, up-tempo and club-oriented Southern hip hop rhythms, the song peaked at the summit of the U.S. Billboard Hot 100.
The song was a massive success worldwide and was the longest running number-one single of 2008 in the United States. With over 6 million digital downloads, it has been certified 7× Platinum by the RIAA, and was the most downloaded single of the 2000s decade, measured by paid digital downloads. The song was named 3rd on the Billboard Hot 100 Songs of the Decade. "Low" spent ten consecutive weeks on top of the Billboard Hot 100, the longest-running number-one single of 2008.
X-Dream are Marcus Christopher Maichel (born May 1968) and Jan Müller (born February 1970); they are also known as Rough and Rush. They are some of the cult hit producers of psychedelic trance music and hail from Hamburg, Germany.
The latest X-Dream album, We Interface, includes vocals from American singer Ariel Electron.
Muller was educated as a sound engineer. Maichel was a musician familiar with techno and reggae, and was already making electronic music in 1986. In 1989 the pair first met when Marcus was having problems with his PC and someone sent Jan to help fix it. That same year they teamed up to work on a session together. Their first work concentrated on a sound similar to techno with some hip hop elements which got some material released on Tunnel Records.
During the early 1990s they were first introduced to the trance scene in Hamburg and decided to switch their music to this genre. From 1993 they began releasing several singles on the Hamburg label Tunnel Records, as X-Dream and under many aliases, such as The Pollinator. Two albums followed on Tunnel Records, Trip To Trancesylvania and We Created Our Own Happiness, which were much closer to the original formula of psychedelic trance, although featuring the unmistakable "trippy" early X-Dream sound.
Radio is the fifth and latest studio album by Jamaican reggae and hip-hop artist Ky-Mani Marley, released on September 25, 2007. It topped the Billboard Reggae Charts at #1 in October 2007. The album features much more hip hop influences than his previous releases.
60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.
The cell's ribosomal protein L40 (rpL40), a part of the large 60S subunit. rpL40 is used by certain RNA viruses to translate messenger RNAs (mRNAs) into proteins while few host mRNAs require rpL40. Hence targeting this protein may provide a means to combat viral infections with minimum side effects to the host.
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation, or ubiquitination, to mark cellular proteins for degradation. Specifically, UBA1 catalyzes the ATP-dependent adenylation of ubiquitin (Ub), thereby forming a thioester bond between the two. It also continues to participate in subsequent steps of ubiquination as a Ub carrier. UBA1 is one of only two human ubiquitin-activating enzymes (E1), the other being UBA6, and thus is largely responsible for protein ubiquitination in humans. Through its central role in ubiquitination, UBA1 has been linked to cell cycle regulation, endocytosis, signal transduction, apoptosis, DNA damage repair, and transcriptional regulation. Additionally, UBE1 helps regulate the NEDD8 pathway, thus implicating it in protein folding, as well as mitigating the depletion of ubiquitin levels during stress.
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.
This gene encodes a member of the E1-like activating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
COM DENES LIMA & EDÍLSON PAIVA
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COM DENES LIMA & EDÍLSON PAIVA
COM DENES LIMA & EDÍLSON PAIVA
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COM DENES LIMA & EDÍLSON PAIVA
COM DENES LIMA & EDÍLSON PAIVA
COM DENES LIMA & EDÍLSON PAIVA
"Low" is the debut single by American rapper Flo Rida, featured on his debut studio album Mail on Sunday and also featured on the soundtrack to the 2008 film Step Up 2: The Streets. The song features fellow American rapper T-Pain and was co-written with T-Pain. There is also a remix in which the hook is sung by Flo Rida rather than T-Pain. An official remix was made which features Pitbull and T-Pain. With its catchy, up-tempo and club-oriented Southern hip hop rhythms, the song peaked at the summit of the U.S. Billboard Hot 100.
The song was a massive success worldwide and was the longest running number-one single of 2008 in the United States. With over 6 million digital downloads, it has been certified 7× Platinum by the RIAA, and was the most downloaded single of the 2000s decade, measured by paid digital downloads. The song was named 3rd on the Billboard Hot 100 Songs of the Decade. "Low" spent ten consecutive weeks on top of the Billboard Hot 100, the longest-running number-one single of 2008.